The v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), a member of a large family of GTP-binding proteins involved in signal transduction [53, 54], plays an important role in colorectal carcinogenesis because a high percentage of colorectal carcinomas are characterized by activating mutations of this oncogene [45]. The gene discussed is KRAS; the disease is colorectal carcinoma.