Previously, we have demonstrated that lymphocyte apoptosis in hypertrophic adenoid in children with otitis media with effusion more enhanced than in the HA group, which seems to be due to the fact that in hypertrophic adenoid of OME children the percentage of CD4+ and CD8+ lymphocytes with Fas expression was higher compared with the group without the inflammation, whereas the percentage of these cells with Bcl-2 expression was lower [3]. This evidence concerns the gene BCL2 and otitis media with effusion.