Spinal cord specimens from patients with NMO typically show evidence of perivascular inflammatory demyelination with high proportion of polymorphonuclear cells (PMN) and eosinophils, deposition of IgM and complement C9 neoantigen in addition to hyalinization of spinal cord arteries with gray and white matter necrosis [102, 129, 132-135]. Here, CD40LG is linked to neuromyelitis optica.