ERBB4 and schizophrenia: These and other studies are beginning to reveal significant defects in neural structure and function resulting from a compromised NRG signaling pathway and may begin to provide insight into the potential relationship between ErbB-NRG signaling and schizophrenia, initially based upon the identification of Nrg1 and ErbB4 as susceptibility genes in schizophrenia [40-46].