However, although recent publication of Guidelines for Head and Neck Cancer [National Comprehensive Cancer Network (NCCCN) GuidelinesTM Version 1.2011 Head and Neck Cancers] suggests p16-IHC as a screening method for HPV detection [19], some questions remain regarding the accuracy of the test when used alone, without molecular detection of HPV-DNA. The gene discussed is CDKN2A; the disease is cancer.