As shown in neuroblastoma, by down-regulating HIF-2α in stem cell-like cells, sympathetic neuronal differentiation can be induced (21), and we speculate that HIF-2 inhibition could be a strategy to push immature stem cell-like cells into a more differentiated, bulk-like cell population that can be treated by established treatment protocols. The gene discussed is EPAS1; the disease is neuroblastoma.