PTP4A2 and cancer: As expected, PRL-2 antibody therapy to PRL-2 expressing cancers was unsuccessful (Fig. S3C), and PRL-2 antibody-treated mice died 1-week earlier or showed worse outcome than ‘untreated’ mice, likely due to the side effect of anti-PRL-2 antibody causing normal PRL-2-expressing tissues to be targeted by the PRL-2 antibodies.