Using a Tg(Fli:GFP) endothelial reporter transgenic zebrafish line with fluorescent vasculature 25, we found that the accumulated tumour cells induced neovasculature formation and developed into a localized tumour (Figure 1C–E), whereas the disseminated tumour cells formed micrometastic colonies in the trunk of the fish (Figure 1F–H). The gene discussed is FLII; the disease is neoplasm.