VEGFA and neoplasm: Angiogenesis in some cancers can directly enhance tumour aggressiveness and chemoresistance by activating growth, survival, proliferation and anti-apoptotic signalling pathways through angiogeneic moieties such as basic fibroblast growth factor, vascular endothelial growth factor and platelet-derived growth factors (Yang et al, 2009; Linderholm et al, 2010; Carmo et al, 2011).