From our modeling, if all individuals with advanced NSCLC are screened for ALK positivity by FISH and the 1.6% who are found to positive are treated and gain 0.83 QALYs each, the total gain across the population will be ∼0.013 QALYs (∼5 extra days of perfect life) per individual screened. The gene discussed is ALK; the disease is non-small cell lung carcinoma.