In contrast, the Myc mRNA and protein over-expression that is observed in 70-80% of colon carcinomas (Smith and Goh, 1996) results from aberrant transcriptional control of the MYC locus involving mutations in APC-b-catenin-TCF-4 pathway members (Barker et al., 2000). The gene discussed is MYC; the disease is colon carcinoma.