MITF and melanoma: Previously, we have reported that hirsein B (HB) or 5β-hydroxyresiniferonol-6α,7α-epoxy-12β-coumaroyloxy-9,13,14-ortho-decanoate from Thymelaea hirsuta [4] has antimelanogenesis effect (without cytotoxicity) on B16 murine melanoma cells by downregulating the expressions of the Mitf gene and the melanogenic enzymes’ genes [5].