Based on the corresponding IC50 values of IPC1755, DPIV (0.06 μM), APN (0.03 μM) and/or cAAP (0.02 μM), rather than DPII (166 μM) or DP8/9 (85 μM), might serve as its potential targets in cerebral ischemia. The gene discussed is ANPEP; the disease is brain ischemia.