The involvement of DPIV, APN and DPIV-/APN-like proteases in ischemia-triggered signaling cascades was confirmed by the ability of the non-selective inhibitor of DPIV and APN protease activity IPC1755 (10 μM) to reduce cortical lesion sizes and to promote neuronal cell survival after a transient focal ischemia due to eMCAO. This evidence concerns the gene ANPEP and ischemia.