RAF1 and dengue disease: The ligand-based screening was carried out using the EDULISS (EDinburgh University LIgand Selection System) program.<h4>Results</h4>The selection of potential inhibitors of dengue NS5 MTase was based on two criteria: the compounds must bind to NS5 MTase with a higher affinity than that of active NS5 MTase ligands, such as ribavirin triphosphate (RTP) and S-adenosyl-L-homocysteine (SAH); and the compounds must interact with residues that are catalytically important for the function of NS5 MTase.