Consistent with our previous cross with the MMTV-NDL2-5 strain, MMTV-NIC animals homozygous for both conditional FAK alleles exhibited a significant delay in tumour onset (Figure 5a) that was further associated with a deficit in the number of pre-malignant lesions in the adjacent mammary glands of tumour-bearing mice (Figure 5c and 5e) as well as in 4-month-old tumour-free mice (Figure 5d and 5f). This evidence concerns the gene PTK2 and neoplasm.