While these data implicate the Pyk2/FAK/p130Cas signalling complex as an important signalling element in ErbB2 tumour progression, both ILK- and β-1 integrin-ablated ErbB2 tumours lack detectable tyrosine phosphorylated p130Cas [26,27] indicating that tyrosine phosphorylation of the p130Cas scaffold is not essential for ErbB2 tumour induction. The gene discussed is PTK2; the disease is neoplasm.