However, in contrast to complete loss of tyrosine phosphorylation of p130Cas in an ErB2 model with abrogation of either β1-integrin or integrin linked kinase (ILK) [26,27], FAK-deficient tumours still retained a basal level of tyrosine-phosphorylated p130Cas that was further correlated with its ability to couple with the FAK-related kinase Pyk2 (Figure S4 in Additional file 4 and Figure S5d in Additional file 5). This evidence concerns the gene PTK2 and neoplasm.