To the best of our knowledge, this is the first report demonstrating that both LAT1 and 4F2hc were expressed in vascular endothelia of human brain gliomas, indicating that the LAT1/4F2hc complex plays an important role in large neutral amino acids permeating the blood-brain barrier (BBB) in human brain gliomas. The gene discussed is SLC3A2; the disease is brain glioma.