In this series of glioma specimens, Ki-67 LI markedly correlated with the glioma pathological grade, and Ki-67 LI in high grade glioma tissues was significantly higher than that in low grade glioma tissues, suggesting that tumor cell proliferative activity obviously enhances with the increase in the glioma pathological grade, which was in agreement with the previous reports [19]. This evidence concerns the gene MKI67 and glioma.