In order to study the affect of CTLA4 blockade on the sialadenitis and xerostomia associated with Sjögren's syndrome, CTLA4IgG was locally expressed in the salivary glands of C57BL/6.NOD-Aec1Aec2 mice, which develop a Sjögren's syndrome-like disease. The gene discussed is CTLA4; the disease is Sjogren syndrome.