Beyond that, ABCA1 has been implicated in insulin secretion from pancreatic beta cells [50], and some single nucleoide polymorphisms (SNPs) of this gene have been demonstrated to associate with dementia (rs2230805) [51] and Alzheimer's disease (rs1800977 and rs2422493) [52]. This evidence concerns the gene ABCA1 and early-onset autosomal dominant Alzheimer disease.