PDCD6 and ovarian carcinoma: In early stage tumors or tumors other than ovarian cancer, PDCD6 may have a pro-apoptotic effect on the tumors, whereas in our case when the tumor is ovarian cancer or tumors progress to advanced stages (since most of ovarian cancers are grade 3 tumors), the PDCD6 function changes to an opposite direction either due to different regulation or downstream targets, which is anti-apoptotic or pro-migration that leads to shortened progression-free survival.