The GENECARD proband-CATHGEN case/control validation cohort analysis resulted in 132 significant SNPs in 60 distinct genes (Additional File 7 Table S1), with the most significant evidence for association with CAD for SNPs in ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH) (rs6895094, p = 0.0001) and the transcript CTB-99A3.1 (rs11744339, p = 0.0003), which overlaps the genomic location of PPP2R2B. This evidence concerns the gene ARHGAP1 and coronary artery disorder.