PPP2R2B and coronary artery disorder: In the GENECARD sample, 102 SNPs in 45 distinct genes were significantly associated with CAD using APL (Additional File 4 Table S1); the most significant results were SNPs in the genes PPP2R2B (rs7736604, p = 0.0003) and SPOCK1 (rs17170899, p = 0.003).