We conclude from our studies that Bacopa monnieri and Bacoside-A treatment potentiates a therapeutic effect by reversing the alterations in general GABA, GABAA, GABAB receptor binding, GABAA receptor subunits, GAD and CREB gene expression that occur during epilepsy, resulting an increased GABA mediated inhibition in the over stimulated cerebral cortex neurons. Here, CREB1 is linked to epilepsy.