CCN1 and wet macular degeneration: Examples of wet AMD candidate targetswithin the RPE-choroid interactome (Figure 4) includeIGF2, an imprinted gene adjacent to H19 (also in Figure 4) whose product up-regulates VEGF expression [138], CYR61, a matricellular protein that modulates angiogenesis and apoptosis [139], and SPP1, a matricellular CFH binding protein that is both a promoter ofVEGF-induced endothelial migration and an immunomodulator [140,141].