C3 and age-related macular degeneration: Other studies identified AMD risk variants in additional complement-relatedgenes (for example, C2, CFB, CFHR1/3, C3) [19-22] as well as in a variety of non-complement-related genes, including a locus ofunknown functional relevance (for example, ARMS2/HTRA1) [23-26] and loci related to lipid metabolism (APOE, LIPC,ABCA1) [27-33].