Interestingly, a recent study in AQP4-knockout mice found that experimental autoimmune encephalomyelitis (EAE) was attenuated in comparison to wild-type mice, which implicates AQP4 as a novel disease determinant of the severity of EAE and likely other autoimmune disorders of the CNS [54]. This evidence concerns the gene AQP4 and experimental autoimmune encephalomyelitis.