Although the reason why sVEGFR-2 levels are decreased in DHF and DSS patients is not clear, as VEGF binding to VEGFR-2 on endothelial cells results in receptor phosphorylation, changes in endothelial cell morphology and proliferation, and maintenance of physiological condition of blood vessels, decreased sVEGFR-2 levels in severe Dengue patients might represent the dysfunction of homeostasis in vascular endothelial cells and correlate with increased plasma leakage [49]. This evidence concerns the gene VEGFA and dengue disease.