Given that the exposure to IFN has been shown to transiently activate macrophages with sCD14 release [50], and that CD14+ monocytes of HIV-infected patients display higher ISG expression [51], our data that patients with cirrhosis, 1–4 genotypes and non-responders show increased sCD14 despite equal plasma LPS, allow to hypothesise in these individuals an overall higher innate immune activation with higher endogenous IFN, that results in sCD14 release, while rendering the cells less sensitive to exogenous IFN. This evidence concerns the gene CD14 and Cirrhosis.