For example, 14% (11/76) of the SLE patients showed pure Sm/RNP reactivity without immunoreactivity against Ro or La antigens, while 17% (13/76) of the SLE patients demonstrated a pure Ro/La reactivity without immunoreactivity against Sm, RNP-A or RNP-70k (Fig. 1). Here, SSB is linked to systemic lupus erythematosus.