Evaluation of six of the major SLE antigens (RNP-A, RNP-70k, Sm-D3, La, Ro52 and Ro60) with LIPS disclosed a wide dynamic range of detectable antibody titers with significant differences in the GMTs for each antigen between the SLE patients and the control group (Table 2). The gene discussed is SSB; the disease is systemic lupus erythematosus.