AURKA (aurora kinase A) is an important gene located at 20q13.2–20q13.33 which we found to be significantly amplified in left sided tumors compared to right sided tumors (20/67 vs. 0/19) suggesting Aurora kinase inhibitors may be effective in left sided CRC but may not be suitable for right sided CRC. Here, AURKA is linked to colorectal carcinoma.