The amplification of SPRY2 in low-grade tumors as well as lymph node negative tumors (see below) may play an important role by inhibiting the tumor growth and invasion function of FGF. When we looked at cytogenetic changes associated with staging, we found that amplification of 20q13 and deletion of 1p35 were more frequent in stage 1 tumors, compared to stage 2 and 3; where as amplification of 5p12 was more frequently seen in stage 2. The gene discussed is SPRY2; the disease is neoplasm.