As for example, Varenciline (an approved drug for smoking cessation) or AZD1446 (phase II completed for cancer and Alzheimer's disease) are agonists for CHRNA4 (cholinergic nicotinic receptor) and can be tested whether it would be useful to prevent or delay the lymph node metastasis in CRC. The gene discussed is CHRNA4; the disease is early-onset autosomal dominant Alzheimer disease.