The combination of erlotinib with the IGF1R monoclonal antibody, R1507, did not reveal a statistically significant improvement in PFS or OS in NSCLC [94] though investigations with another IGFR1 monoclonal antibody, cixutumumab, in the treatment of SCLC and NSCLC are currently ongoing [96], [97]. The gene discussed is IGF1R; the disease is non-small cell lung carcinoma.