SREBF1 and obesity due to melanocortin 4 receptor deficiency: To determine if the phenotype of obesity and hepatic lipid accumulation due to over-expression of human transcripitonally active N-terminal domain of human SREBP-1c is associated with increased secretion of inflammatory and proinflammatory parameters from adipose tissue, a set of 40 chemokines and cytokines was analyzed in the secretom of isolated adipocytes of control and transgenic animals (Figure 6).