These data highlight the central role of IL-15 γc-signaling in renal epithelial homeostasis and strengthen the fact that the loss of the γc chain in renal clear cell adenocarcinomas could represent a mechanism that through E-cadherin down-regulation not only favors EMT but may also affect trafficking, survival and functions of different subsets of CD8+ cells. Here, IL15 is linked to clear cell renal carcinoma.