CDH1 and renal cell carcinoma: By contrast, five days of rhIL-15 treatment (10 pg/mL) induced the opposite effects on RCC, causing not only the decrease of E-cadherin on RCC (Figure 4A), but also favoring the acquisition of a mesenchymal-like phenotype, as shown by the loss of epithelial markers (cytokeratins and ZO-1) and by the enhancement of vimentin and α-SMA stress fibers networks (Figure 7A).