IL2RB and renal cell carcinoma: To confirm the presence of an IL-15Rα/IL-2Rβ complex heterodimer, the potential interactions between the IL-15Rα and IL-2Rβ chains in RCC were investigated performing co-immunoprecipitation experiments on RCC7 cell lysates by immunoadsorption to Sepharose-conjugated anti-IL-15Rα (M161) (Figure 3B).