Recent data from the Framingham Heart Study support the hypothesis that an impaired t-PA release may increase the risk for permanent flow-arresting thrombi, as the t-PA enhancer −7,351C/T polymorphism (generating a low-secretor phenotype) was found to be associated with a more than 3-fold adjusted increased risk for myocardial infarction [1]. Here, PLAT is linked to myocardial infarction.