To investigate the possible mechanism for the regulation of DPEP1 expression in pancreatic cancer, we examined the levels of DPEP1 in Panc1 cells in response to EGF (30 nM), MEK1/2 inhibitor AZD6244 (1.5 μM) and PI3K inhibitor LY294002 (1.5 μM). This evidence concerns the gene MAP2K1 and familial pancreatic carcinoma.