Although this observation seems counterintuitive in terms of selective criteria, considering the relative small sample sizes even in the present meta-analysis and the possibility that (CAG)n polymorphism might not be a major contributing locus or have limited values to assess an exact role of MEF2A in CAD/MI, we maintain that application of coronary angiographic criteria for controls is preferable, and the proper phenotype discrimination is critical in any genetic association study. This evidence concerns the gene MEF2A and coronary artery disorder.