As shown in Fig. 3B, sterol regulatory element binding protein-1c (SREBP-1c) and stearoyl CoA desaturase-1 (Scd-1) mRNA, which are key regulators of the de novo hepatic lipogenesis pathway, were decreased by exendin-4 treatment in HF- induced obese C57BL/6J mice. The gene discussed is SCD; the disease is hydrops fetalis.