HIV-1 infected subjects with liver disease were not different from HIV-1 infected subjects without liver disease in serum active α1PI (p = 0.95), serum total α1PI (p = 0.79), CXCR4+ lymphocytes (p = 0.63), or CCR5+ lymphocytes (p = 0.9), but exhibited significantly higher serum CXCL12 (p<0.001), HLECS+ lymphocytes (p<0.001), and CD4+ lymphocytes (p = 0.04). The gene discussed is CXCR4; the disease is liver disorder.