HPSE and cancer: Stable transfection of shP3 (−9/+10 bp) and shCd (+1496/+1515 bp), but not of shP2 (−134/−115 bp) or scrambled shRNA (shScb), resulted in attenuated mRNA and protein levels of heparanase (Fig. S4B, and Fig. S4C), and decreased in vitro proliferation of cancer cells (Fig. 5A, Fig. 5B and Fig. 5C).