To further investigate the role of Brg1 as a tumor suppressor, we now report the results of experiments that demonstrate a relationship between the normal transcriptional activity of the Brg1, Brm and Whey acidic protein (Wap) genes, and the effect on viability and transformation of Wap-activated deletion of Brg1 in the presence or absence of Brm. Here, SMARCA4 is linked to neoplasm.