Prior studies showed that the protective effect of a Leu→Met substitution at amino acid 237 (L237M) of ND2 (C5178A) against oxidative damage to mitochondria not only contributes to human longevity [13], [16], but also provides strong anti-atherosclerotic effects in diabetic patients and protects against myocardial infarction [14]. This evidence concerns the gene MT-ND2 and myocardial infarction.