Spikiness also marks other endocrine physiology and pathophysiology, such as greater survival when applied to serial glucose data in patients with protracted critical illness, older age in women when applied to ACTH time series, sharper TSH excursions in hypothyroidism and thyrotropinoma compared with normal, and unstable premenstrual mood-rating dynamics in dysphoria and response to therapy in the latter group [13], [66]–[68]. The gene discussed is POMC; the disease is hypothyroidism.