Still, high resolution comparative genomic hybridization revealed a number of chromosomal regions with gains and losses in MCC; the frequent loss of chromosome 10 where the tumor suppressor gene phosphatase and tensin homologue (PTEN) is encoded, suggests that aberrations of the PI3K/AKT pathway may be involved in the pathogenesis of MCC [6]. The gene discussed is PTEN; the disease is Merkel cell skin cancer.