Wang et al. showed that Chrysanthemum indicum ethanolic extract (CIE) suppressed the proliferation and invasion of HCC cells lines (MHCC97H cells) substantially, with notable decreases in MMP-2 and MMP-9 expression and simultaneous increases in TIMP-1 and TIMP-2 expression [26]. This evidence concerns the gene TIMP1 and hepatocellular carcinoma.