It is interesting, albeit unexplained, to find that in our study the negative prognostic value for survival in patients with high DCN expression in malignant cells was clearly significant in Luminal B cases (i.e. ER-positive, HER2-positive) (HR: 2.33 p = 0.002) while lacking any survival prognostic effect on ER only or HER2 only positive tumours. The gene discussed is ESR1; the disease is neoplasm.