Given that vascular endothelial growth factor-A, a potent pro-angiogenic factor, is down-stream of the EGFR pathway which is in turn increased by HSP90, it may be that high levels of HSP90 could promote metastasis, and in fact an association between high HSP90 expression and metastasis in melanoma has been reported previously. Here, HSP90AB1 is linked to melanoma.