A comprehensive study encompassing all Notch ligands and receptors in chronic kidney diseases showed that cleaved Notch1, Notch2, and Jagged1 expressionin podocytes in proteinuric nephropathies was correlated with the amount of proteinuria, and the expression of cleaved Notch1 in the tubulointerstitium was correlated with the severity of tubulointerstitial fibrosis [55]. Here, NOTCH1 is linked to chronic kidney disease.