In order to follow-up the prior identification that three DISC1 SNPs (rs821577, rs821633 and rs1538979) modify risk to schizophrenia and bipolar disorder dependent on interplay [2], we studied these SNPs in relation to four psychometric scales evaluated in the Northern Finland Birth Cohort 1966 (NFBC66). The gene discussed is DISC1; the disease is schizophrenia.