CD8A and lymphopenia: As Rag1−/− mice were T/B cell deficient and might drive extensive homeostatic proliferation of naive T cells due to lymphopenia [24], we therefore adoptively transferred CD45.2+Tsc1 KO or CD45.2+WT naïve CD8+T cells into 4Gy-irriadiated immunocompetent CD45.1+syngeneic C57BL/6 recipients (Fig. 3G).