Moreover, curcumin-mediated inhibition of Notch-1 activation also led to the downregulation of NF-κB and its target genes, including Bcl-2, cyclin D1, vascular endothelial growth factor (VEGF), and matrix metalloproteinase -9 (MMP-9) in oral squamous cell carcinoma cells [4]. Here, MMP9 is linked to oral cavity squamous cell carcinoma.