Taken together with the finding that the A allele at rs9929218 is associated with decreased risk of colorectal cancer (OR = 0.91; p = 1.2×10−8) [3], our observation of an association between this allele and decreased DDX28 and NOL3 expression in adjacent normal tissue suggests that these genes may lower risk of colorectal cancers by functioning to inhibit early events of colorectal carcinogenesis. The gene discussed is DDX28; the disease is colorectal cancer.