AKT1 and neoplasm: Figure S4 shows representative stainings of (+), (++) or (+++) AKT1 expression in SCCs and ADCs. Tumours were classified into a low expression group comprising (−) and (+) and a high expression group that comprises (++) and (+++). We observed p110α overexpression in ∼29% of NSCLCs (27/92): 12 out of 34 were SCCs (35%) and 12 out of 43 were ADCs (28%) (Figure 4A and 4B). At difference with other genes within the pathway that have been analysed, we found that NSCLCs with overexpressed p110α presented significantly activated AKT (18 out of 26; p = 0.02) (Table 3).