PPARG and obesity due to melanocortin 4 receptor deficiency: Animal studies have suggested that BPA exposure may have a role in the development of hypertension thorough several mechanisms, including BPA's role in weight gain and obesity development potentially through its actions on preadipocytes [23, 24], role as an estrogen [5], potential interactions with estrogen-related receptor gamma [25], actions as a thyroid hormone antagonist [4], role as a peroxisome proliferator-activated receptor gamma antagonist [26], and its role in influencing pancreatic endocrine function [27].