It has been reported that HSP60 and other proteins like Ku70 binding protein, alpha enolase, and 26S proteasome subunit were up-regulated in the E7 oncogene in HPV-negative cervical cancer cell line (C33A), suggesting that the up-regulation of HSP60 by E7 oncogene could be one of the essential factors associated with resistance of apoptosis [56]. Here, ENO1 is linked to cervical carcinoma.